Cardiac Markers Blood Test

Introduction

Cardiac markers are substances released into the blood when the heart is damaged or stressed. Doctors use blood tests to measure these markers and diagnose heart conditions, particularly heart attacks (myocardial infarction).

Key Cardiac Markers

1. Troponins (Troponin I and Troponin T)

  • Most specific and sensitive marker for heart muscle damage.
  • Levels rise within 3-6 hours after heart damage and stay elevated for up to 14 days.

2. Creatine Kinase-MB (CK-MB)

  • Rises 3-6 hours after damage, peaks at 18-24 hours, and normalizes within 2-3 days.
  • Less specific than troponins but still useful for detecting reinfarction.

3. Myoglobin

  • Appears in blood very early (1-4 hours) after heart muscle injury.
  • Fast clearance from the blood makes it less specific.

4. B-type Natriuretic Peptide (BNP) and NT-proBNP

  • Used to assess heart failure rather than heart attacks.
  • High levels suggest poor heart function.

When Are Cardiac Markers Tested?

  • Suspected heart attack (chest pain, shortness of breath, sweating, nausea).
  • Monitoring of heart conditions in critically ill patients.
  • Evaluating treatment response in heart diseases.

What Do Abnormal Results Mean?

  • Elevated troponin → Possible heart attack or severe heart stress.
  • High CK-MB → Suggests recent heart muscle damage.
  • High BNP → Indicates heart failure.

Conclusion

If you are experiencing symptoms of a heart problem, your doctor may order these tests. Early detection and treatment can save lives, so understanding these markers is essential.

Source recommendations

1. American Heart Association Guidelines

  1. https://professional.heart.org/en/guidelines-and-statements
  2. https://www.heart.org/
  3. https://professional.heart.org/en/guidelines-statements
  4. https://www.heart.org/en/healthy-living/fitness/fitness-basics/aha-recs-for-physical-activity-in-adults
  5. https://cpr.heart.org/en/resuscitation-science/cpr-and-ecc-guidelines

2. European Society of Cardiology Guidelines on Acute Coronary Syndromes

  1. https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Acute-Coronary-Syndromes-ACS-Guidelines
  2. https://academic.oup.com/eurheartj/article/44/38/3720/7243210
  3. https://pubmed.ncbi.nlm.nih.gov/37622654/
  4. https://www.ahajournals.org/doi/10.1161/CIR.0000000000001309
  5. https://pubmed.ncbi.nlm.nih.gov/26320110/

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