The Cardiac Sphincter: Function, Problems, and Treatment

Introduction

The cardiac sphincter, also known as the lower esophageal sphincter (LES), is a muscular ring at the junction of the esophagus and the stomach. Its primary function is to prevent stomach acid from flowing back into the esophagus, which helps protect the delicate lining of the esophagus from damage.

Function of the Cardiac Sphincter

  • The sphincter remains closed to prevent acid reflux but relaxes during swallowing to allow food and liquids to pass into the stomach.
  • It works in coordination with the diaphragm to maintain pressure and prevent acid backflow.

Common Disorders of the Cardiac Sphincter

1. Gastroesophageal Reflux Disease (GERD)

  • GERD occurs when the cardiac sphincter weakens or relaxes inappropriately, allowing stomach acid to enter the esophagus.
  • Symptoms: Heartburn, regurgitation, chest pain, and difficulty swallowing.
  • Risk Factors: Obesity, smoking, certain foods (spicy, fatty, or acidic), and certain medications.
  • Complications: Esophagitis, Barrett's esophagus, and an increased risk of esophageal cancer.

2. Achalasia

  • A rare condition where the sphincter fails to relax properly, leading to difficulty in swallowing.
  • Symptoms: Regurgitation, chest pain, and weight loss.

3. Hiatal Hernia

  • Part of the stomach pushes through the diaphragm, affecting sphincter function.
  • Symptoms: Often similar to GERD, including heartburn and chest pain.

Management and Treatment

1. Lifestyle Modifications

  • Maintain a healthy weight.
  • Avoid foods that trigger reflux.
  • Eat smaller portions and avoid eating close to bedtime.
  • Elevate the head of your bed.

2. Medications

  • Proton Pump Inhibitors (PPIs): Reduce stomach acid production (e.g., omeprazole, pantoprazole).
  • H2 Receptor Blockers: Less potent acid reducers (e.g., ranitidine, famotidine).
  • Antacids: Neutralize stomach acid temporarily.

3. Surgical Interventions

  • Fundoplication: Wrapping the top of the stomach around the esophagus to strengthen the sphincter.
  • Balloon Dilation (for achalasia): Expanding the sphincter using a balloon during an endoscopy.

Conclusion

The cardiac sphincter plays a crucial role in digestion and the prevention of acid reflux. When its function is impaired, conditions like GERD, achalasia, or hiatal hernia may develop. Proper lifestyle changes, medications, and sometimes surgical interventions can help manage these conditions effectively.

Source recommendations

1. American College of Gastroenterology Guidelines for the Management of GERD

  1. https://gi.org/guidelines/
  2. https://journals.lww.com/ajg/fulltext/2022/01000/acg_clinical_guideline_for_the_diagnosis_and.14.aspx
  3. https://gi.org/topics/acid-reflux/
  4. https://pmc.ncbi.nlm.nih.gov/articles/PMC8754510/
  5. https://pubmed.ncbi.nlm.nih.gov/34807007/

2. European Society of Gastrointestinal Endoscopy Guidelines

  1. https://www.esge.com/publications/guidelines
  2. https://pubmed.ncbi.nlm.nih.gov/35523224/
  3. https://www.esge.com/
  4. https://pubmed.ncbi.nlm.nih.gov/33567467/
  5. https://pmc.ncbi.nlm.nih.gov/articles/PMC4789831/

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