Cardiac Sphincter Function

Introduction

The cardiac sphincter, also known as the lower esophageal sphincter (LES), plays a crucial role in digestion and overall health. It is a muscular ring located at the junction between the esophagus and the stomach, controlling the passage of food and preventing stomach acid from flowing back into the esophagus.

Function of the Cardiac Sphincter

1. Prevention of Acid Reflux

  • The LES remains tonically contracted to prevent stomach contents from regurgitating into the esophagus.
  • During swallowing, it relaxes to allow food and liquids to pass into the stomach.

2. Protection from Gastroesophageal Reflux Disease (GERD)

  • If the LES becomes weak or relaxes inappropriately, acid from the stomach can enter the esophagus, leading to heartburn, esophagitis, and GERD.

3. Role in Digestion

  • Ensures one-way movement of ingested material.
  • Maintains an effective barrier between acidic and non-acidic environments, protecting the esophageal mucosa.

Common Disorders of the Cardiac Sphincter

1. Gastroesophageal Reflux Disease (GERD)

  • Symptoms: Heartburn, acid regurgitation, chest pain, chronic cough.
  • Causes: Obesity, hiatal hernia, smoking, poor diet, certain medications.

2. Achalasia

  • A condition where the LES fails to relax properly, causing difficulty in swallowing (dysphagia), regurgitation, and weight loss.

3. Hiatal Hernia

  • A condition where part of the stomach moves up through the diaphragm, weakening LES function and leading to acid reflux.

Treatment and Management

1. Lifestyle Modifications

  • Avoid large meals and eating close to bedtime.
  • Reduce intake of acidic foods, caffeine, and alcohol.
  • Maintain a healthy weight.

2. Medications

  • Proton pump inhibitors (PPIs) to reduce acid production.
  • H2 blockers to lower acid levels.
  • Prokinetics to improve LES tone and motility.

3. Surgical Options

  • Fundoplication: A procedure where the stomach is wrapped around the LES to strengthen it.
  • Endoscopic procedures: Such as Stretta therapy, which uses radiofrequency energy to improve LES function.

Conclusion

The cardiac sphincter is essential for preventing acid reflux and ensuring proper digestion. Weakness or dysfunction of this sphincter can result in GERD or other digestive disorders, which can often be managed through lifestyle changes, medications, or surgical interventions.

Source recommendations

1. American Gastroenterological Association Guidelines

  1. https://gastro.org/clinical-guidance/
  2. https://gi.org/guidelines/
  3. https://gastro.org/practice-resources/practice-tools/
  4. https://www.gastrojournal.org/content/agai
  5. https://gastro.org/

2. American College of Gastroenterology Guidelines

  1. https://gi.org/guidelines/
  2. https://gastro.org/clinical-guidance/
  3. https://gi.org/journals-publications/acgbooks_guide2guidelines/
  4. https://journals.lww.com/ajg/fulltext/2024/03000/american_college_of_gastroenterology_guidelines_.14.aspx
  5. https://gi.org/guideline/

3. European Society of Gastrointestinal Endoscopy Guidelines

  1. https://www.esge.com/publications/guidelines
  2. https://pubmed.ncbi.nlm.nih.gov/35523224/
  3. https://www.esge.com/
  4. https://pubmed.ncbi.nlm.nih.gov/33567467/
  5. https://www.giejournal.org/article/S0016-5107(23)03148-6/abstract

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