High CRP and Cardiovascular Risk

Introduction

C-reactive protein (CRP) is a marker of inflammation in the body. A high CRP level can indicate various health issues, including infections, chronic diseases, and an increased risk of cardiovascular events.

CRP and the Heart

CRP itself does not cause heart disease, but its elevated levels are associated with higher risks of heart attacks and strokes. Chronic inflammation plays a key role in the development of atherosclerosis (plaque buildup in arteries), which can lead to serious cardiovascular complications.

Causes of High CRP

Some common reasons for elevated CRP levels include: - Infections (viral or bacterial) - Chronic inflammatory diseases (rheumatoid arthritis, lupus) - Obesity (fat tissue contributes to inflammation) - Smoking (toxins increase inflammation) - Diabetes (linked to low-grade inflammation) - Hypertension (high blood pressure damages arteries)

How to Reduce CRP and Cardiovascular Risk

1. Lifestyle Changes

  • Healthy Diet: Follow the Mediterranean or DASH diet, rich in vegetables, fruits, and healthy fats.
  • Exercise Regularly: At least 150 minutes of moderate-intensity activity per week.
  • Quit Smoking: Smoking cessation lowers inflammation.
  • Manage Weight: Reducing obesity decreases CRP levels.

2. Medical Management

  • Statins: These cholesterol-lowering drugs can also reduce CRP levels.
  • Aspirin: May be used in some high-risk individuals to lower inflammation.
  • Diabetes Control: Properly managing blood sugar helps lower CRP.
  • Blood Pressure Control: Keeps arteries healthy and reduces inflammation.

Conclusion

While high CRP is not a direct cause of heart disease, it signals increased cardiovascular risk. Addressing inflammation through lifestyle changes and medical therapy can help lower CRP and improve heart health.

Source recommendations

1. American Heart Association Guidelines on Inflammation and Cardiovascular Disease

  1. https://www.heart.org/en/health-topics/consumer-healthcare/what-is-cardiovascular-disease/inflammation-and-heart-disease
  2. https://professional.heart.org/en/research-programs
  3. https://www.heart.org/en/health-topics/consumer-healthcare/what-is-cardiovascular-disease
  4. https://pubmed.ncbi.nlm.nih.gov/12551878/
  5. https://professional.heart.org/en/research-programs/aha-funded-research/strategic-networks/sfrn-on-inflammation-in-cardiac-and-neurovascular-disease

2. European Society of Cardiology Guidelines on Cardiovascular Prevention

  1. https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/CVD-Prevention-Guidelines
  2. https://academic.oup.com/eurheartj/article/42/34/3227/6358713
  3. https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/CVD-and-Diabetes-Guidelines
  4. https://pubmed.ncbi.nlm.nih.gov/34458905/
  5. https://www.ahajournals.org/doi/10.1161/cir.0000000000000678

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