Cardiovascular System Physiology

Introduction

The cardiovascular system (CVS) is responsible for delivering oxygen and nutrients to tissues and removing waste products. It consists of the heart, blood vessels, and blood. Understanding CVS physiology is crucial for diagnosing and managing cardiovascular diseases.

Components of the Cardiovascular System

1. The Heart

The heart functions as a pump and consists of four chambers: - Right atrium (RA): Receives deoxygenated blood from the body. - Right ventricle (RV): Pumps deoxygenated blood to the lungs. - Left atrium (LA): Receives oxygenated blood from the lungs. - Left ventricle (LV): Pumps oxygenated blood to the body.

2. Blood Vessels

Blood vessels distribute blood throughout the body and are classified into: - Arteries: Carry oxygen-rich blood away from the heart (except the pulmonary artery). - Veins: Return deoxygenated blood to the heart (except the pulmonary vein). - Capillaries: Facilitate exchange of gases, nutrients, and waste between blood and tissues.

3. Blood Circulation

There are two main circulatory loops: - Pulmonary circulation: Blood flows from the RV to the lungs and back to the LA. - Systemic circulation: Blood flows from the LV to the body and back to the RA.

Cardiac Cycle

The cardiac cycle consists of two main phases: - Systole: Contraction phase where blood is ejected from the heart. - Diastole: Relaxation phase where the heart fills with blood.

Regulation of the cardiac cycle involves electrical and mechanical coordination.

Electrical Activity of the Heart

The heart has an intrinsic electrical system that generates and controls heartbeat: - Sinoatrial (SA) node: The natural pacemaker of the heart. - Atrioventricular (AV) node: Delays the impulse before passing it to the ventricles. - Bundle of His and Purkinje fibers: Ensure coordinated ventricular contraction.

Blood Pressure and Its Regulation

Blood pressure (BP) is the force exerted by circulating blood on vessel walls. It is regulated by multiple mechanisms: - Cardiac output (CO): Product of heart rate and stroke volume. - Peripheral resistance: Resistance in blood vessels, mainly affected by vessel diameter. - Neural and hormonal control: Sympathetic and parasympathetic nervous system, renin-angiotensin-aldosterone system (RAAS), and other hormonal mechanisms.

Clinical Relevance

Understanding CVS physiology helps in diagnosing and managing conditions such as: - Hypertension (high blood pressure) - Heart failure - Arrhythmias (irregular heartbeats) - Coronary artery disease

Summary

  • The cardiovascular system ensures blood circulation to sustain life.
  • The heart, blood vessels, and regulatory mechanisms work together.
  • Any disturbance in this system can lead to severe health issues, requiring timely medical intervention.

Source recommendations

1. American Heart Association Guidelines

  1. https://professional.heart.org/en/guidelines-and-statements
  2. https://www.heart.org/
  3. https://professional.heart.org/en/guidelines-statements
  4. https://cpr.heart.org/en/resuscitation-science/cpr-and-ecc-guidelines
  5. https://www.heart.org/en/healthy-living/fitness/fitness-basics/aha-recs-for-physical-activity-in-adults

2. European Society of Cardiology Guidelines

  1. https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines
  2. https://academic.oup.com/eurheartj/article/42/34/3227/6358713
  3. https://www.escardio.org/Guidelines
  4. https://academic.oup.com/eurheartj/article/44/39/4043/7238227
  5. https://www.escardio.org/

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