Understanding Ejection Fraction (EF)

Introduction

Ejection fraction (EF) is a key measurement used in cardiology to assess how well the heart pumps blood with each beat. It is expressed as a percentage and represents the proportion of blood pumped out of the left ventricle during each contraction.

Normal and Abnormal Values

  • Normal EF : 50-70%
  • Borderline EF : 41-49% (may indicate early heart dysfunction)
  • Reduced EF : Below 40% (can be a sign of heart failure or cardiomyopathy)

How is EF Measured?

Ejection fraction is commonly measured through imaging techniques such as:

  • Echocardiogram (Ultrasound of the heart) – the most widely used test
  • Cardiac MRI – provides a detailed image of the heart
  • Nuclear Medicine Tests (MUGA scan) – measures EF using radioactive tracers
  • Cardiac Catheterization (Ventriculogram) – invasive test used in some cases

Causes of Reduced Ejection Fraction

A low ejection fraction can result from various heart conditions, including:

  • Heart failure with reduced ejection fraction (HFrEF)
  • Coronary artery disease (CAD) – reduced blood supply to heart muscle
  • Heart attack (myocardial infarction) – damages heart tissue
  • Cardiomyopathy – diseases that affect heart muscle function
  • Valvular heart disease – improper functioning of heart valves

Symptoms of Low Ejection Fraction

A low EF can lead to symptoms such as:

  • Shortness of breath (dyspnea)
  • Fatigue and weakness
  • Swelling in the legs and ankles (edema)
  • Rapid or irregular heartbeat
  • Difficulty exercising

Treatment Approaches

Management depends on the underlying cause and may include:

Medications

  • ACE inhibitors or ARBs – to relax blood vessels and reduce heart strain
  • Beta-blockers – to slow heart rate and improve function
  • Diuretics – to remove excess fluid and reduce symptoms
  • Mineralocorticoid receptor antagonists (MRAs) – to decrease heart stress
  • SGLT2 inhibitors – new drugs shown to benefit heart failure patients

Devices and Surgery

  • Implantable cardioverter defibrillator (ICD) – prevents sudden cardiac death
  • Cardiac resynchronization therapy (CRT) – improves heart efficiency
  • Heart transplant – only in severe cases

Lifestyle Changes

  • Following a heart-healthy diet (low salt, balanced nutrients)
  • Regular physical activity (as recommended by a doctor)
  • Managing risk factors (diabetes, hypertension, high cholesterol)
  • Avoiding smoking and excessive alcohol

Conclusion

Ejection fraction is an important indicator of heart health. If you have a low EF, early diagnosis and treatment can significantly improve your quality of life and prognosis. Consult a cardiologist to discuss the best treatment options for you.

Source recommendations

1. American Heart Association Guidelines on Heart Failure

  1. https://www.ahajournals.org/doi/10.1161/CIR.0000000000001063
  2. https://www.heart.org/en/health-topics/heart-failure
  3. https://professional.heart.org/en/guidelines-and-statements
  4. https://www.heart.org/
  5. https://professional.heart.org/en/guidelines-and-statements/prevent-calculator

2. European Society of Cardiology Guidelines on Heart Failure

  1. https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Acute-and-Chronic-Heart-Failure
  2. https://academic.oup.com/eurheartj/article/42/36/3599/6358045
  3. https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Focused-Update-on-Heart-Failure-Guidelines
  4. https://academic.oup.com/eurheartj/article/44/37/3627/7246292
  5. https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines

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