Etiology of Atrial Flutter

Introduction

Atrial flutter is a type of supraventricular tachycardia characterized by rapid, organized atrial electrical activity. It is commonly associated with structural heart disease and various systemic conditions.

Causes and Risk Factors

1. Structural Heart Disease

  • Coronary artery disease (CAD)
  • Hypertensive heart disease
  • Heart failure
  • Cardiomyopathies (e.g., hypertrophic or dilated cardiomyopathy)
  • Valvular heart disease (especially mitral valve stenosis or regurgitation)
  • Congenital heart defects (e.g., atrial septal defect)

2. Pulmonary Conditions

  • Chronic obstructive pulmonary disease (COPD)
  • Pulmonary embolism
  • Pulmonary hypertension

3. Metabolic and Endocrine Disorders

  • Hyperthyroidism (thyrotoxicosis)
  • Electrolyte imbalances (e.g., hypokalemia, hypomagnesemia)

4. Postoperative Causes

  • After open-heart surgery (e.g., coronary artery bypass grafting, valve replacement)
  • Post-cardiac ablation procedures

5. Substance and Drug Effects

  • Alcohol consumption (especially binge drinking—"holiday heart syndrome")
  • Stimulants (e.g., caffeine, cocaine, amphetamines)
  • Certain medications (e.g., digitalis toxicity, antiarrhythmic drugs like class IC agents)

Pathophysiology

Atrial flutter is typically caused by a reentrant circuit most commonly in the right atrium. This leads to a rapid atrial rate (250-350 bpm) with a characteristic "sawtooth" appearance on ECG (flutter waves).

Conclusion

Understanding the underlying cause of atrial flutter is essential for proper diagnosis and treatment. Addressing risk factors such as heart disease, metabolic imbalances, and lifestyle factors can help manage and prevent atrial flutter.

Source recommendations

1. 2023 European Society of Cardiology Guidelines for the Management of Atrial Fibrillation

  1. https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Atrial-Fibrillation
  2. https://www.ahajournals.org/doi/10.1161/CIR.0000000000001193
  3. https://www.jacc.org/doi/10.1016/j.jacc.2023.08.017
  4. https://pubmed.ncbi.nlm.nih.gov/32860505/
  5. https://www.jacc.org/doi/10.1016/j.jacc.2023.10.021

2. 2023 American Heart Association/American College of Cardiology/Heart Rhythm Society Guideline for the Management of Patients with Atrial Fibrillation

  1. https://www.ahajournals.org/doi/10.1161/CIR.0000000000001193
  2. https://pubmed.ncbi.nlm.nih.gov/38033089/
  3. https://www.hrsonline.org/guidance/clinical-resources/2023-accahaaccphrs-guideline-diagnosis-and-management-patients-atrial-fibrillation
  4. https://www.jacc.org/doi/10.1016/j.jacc.2023.08.017
  5. https://www.hrsonline.org/guidance/clinical-resources

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