Lateral Myocardial Infarction on ECG

Introduction

Lateral myocardial infarction (MI) is a type of heart attack affecting the lateral wall of the left ventricle. The lateral wall receives blood supply primarily from the left circumflex artery (LCx) and sometimes from branches of the left anterior descending artery (LAD). Recognizing lateral MI on an electrocardiogram (ECG) is crucial for timely diagnosis and treatment.

ECG Changes in Lateral MI

To diagnose a lateral MI, we look for characteristic changes in the ECG, specifically in the lateral leads: - Leads involved: I, aVL, V5, and V6. - ST-segment elevation: This is the hallmark of an acute MI. Elevation in these leads suggests infarction in the lateral wall. - Reciprocal ST-segment depression: May be seen in reciprocal leads such as III and aVF. - Q waves: The presence of pathological Q waves in lateral leads suggests a completed infarct.

Causes and Risk Factors

Lateral MI typically results from occlusion of the LCx artery. The major risk factors for MI include: - Hypertension - Hyperlipidemia - Smoking - Diabetes mellitus - Family history of coronary artery disease (CAD) - Sedentary lifestyle and obesity

Clinical Symptoms

Patients with lateral MI may experience: - Chest pain (pressure, squeezing, or burning sensation lasting more than 20 minutes) - Pain radiating to the arm, jaw, or shoulder - Shortness of breath - Nausea, vomiting, dizziness - Profuse sweating (diaphoresis)

Diagnosis

Diagnosis is made based on: 1. ECG findings (ST elevation in lateral leads) 2. Blood tests measuring cardiac biomarkers (troponin levels) 3. Coronary angiography to identify the blocked artery

Treatment

Management of lateral MI focuses on restoring blood flow and preventing complications: - Immediate interventions: - Aspirin and P2Y12 inhibitors (e.g., clopidogrel) to prevent further clot formation - Nitroglycerin to relieve chest pain - Oxygen therapy, if needed - Beta-blockers to reduce myocardial oxygen consumption - Reperfusion therapy: - Primary percutaneous coronary intervention (PCI) – the preferred treatment - Thrombolytic therapy if PCI is not available - Long-term management: - ACE inhibitors or ARBs to prevent heart remodeling - Statins to lower cholesterol - Lifestyle modifications (diet, exercise, smoking cessation)

Conclusion

Lateral MI is a serious cardiac event requiring prompt recognition and treatment. ECG plays a vital role in early diagnosis, and interventions such as PCI significantly improve outcomes. Preventive strategies, including risk factor management, help reduce the incidence of MI.

Source recommendations

1. American Heart Association Guidelines for the Management of ST-Elevation Myocardial Infarction (STEMI)

  1. https://www.ahajournals.org/doi/10.1161/cir.0b013e3182742cf6
  2. https://professional.heart.org/en/science-news/2021-acc-aha-scai-guideline-for-coronary-artery-revascularization
  3. https://www.ahajournals.org/doi/10.1161/01.cir.0000134791.68010.fa
  4. https://pubmed.ncbi.nlm.nih.gov/23256914/
  5. https://www.heart.org/en/health-topics/heart-attack/treatment-of-a-heart-attack

2. European Society of Cardiology Guidelines on Acute Coronary Syndromes in Patients Presenting Without Persistent ST-Segment Elevation

  1. https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Acute-Coronary-Syndromes-ACS-Guidelines
  2. https://academic.oup.com/eurheartj/article/42/14/1289/5898842
  3. https://pubmed.ncbi.nlm.nih.gov/32860058/
  4. https://pmc.ncbi.nlm.nih.gov/articles/PMC5313450/
  5. https://pubmed.ncbi.nlm.nih.gov/21873419/

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