Understanding Polymorphic Ventricular Tachycardia (VT) on ECG

Introduction

Polymorphic Ventricular Tachycardia (VT) is a life-threatening arrhythmia characterized by a rapid heart rate with continuously changing QRS complex morphology. It can lead to syncope (fainting) or sudden cardiac arrest if not promptly managed.

ECG Characteristics

  1. Irregular QRS Morphology: The hallmark of polymorphic VT is that the QRS complexes vary in shape and size from beat to beat.
  2. Rapid Ventricular Rate: Typically, the ventricular rate exceeds 150 beats per minute.
  3. Torsades de Pointes (TdP) Variant: If polymorphic VT occurs in the presence of a prolonged QT interval on a baseline ECG, it is called Torsades de Pointes and requires special treatment.

Causes of Polymorphic VT

Several conditions can predispose someone to polymorphic VT, including: - Electrolyte Imbalances (low potassium, magnesium, or calcium) - Ischemic Heart Disease (e.g., myocardial infarction) - Congenital Long QT Syndrome - Drug-Induced QT Prolongation (e.g., antiarrhythmic drugs, certain antibiotics, and antipsychotics) - Catecholaminergic Polymorphic VT (CPVT) (genetic disorder)

Management and Treatment

  • Immediate Defibrillation: If the patient is unstable, electrical cardioversion or defibrillation is required.
  • Magnesium Sulfate: The first-line treatment for Torsades de Pointes.
  • Correction of Electrolyte Imbalances: Potassium and magnesium supplementation.
  • Withdrawal of QT-Prolonging Drugs: Essential in cases of drug-induced QT prolongation.
  • Beta-Blockers: Used in cases of CPVT to reduce arrhythmic episodes.
  • ICD Placement: An implantable cardioverter defibrillator (ICD) may be needed for high-risk patients.

Conclusion

Recognizing polymorphic VT on ECG and identifying the underlying cause is crucial for effective treatment. Early intervention can prevent life-threatening complications like sudden cardiac death.

Source recommendations

1. 2022 ESC Guidelines on Ventricular Arrhythmias and Sudden Cardiac Death

  1. https://academic.oup.com/eurheartj/article/43/40/3997/6675633
  2. https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Ventricular-Arrhythmias-and-the-Prevention-of-Sudden-Cardiac-Death
  3. https://pubmed.ncbi.nlm.nih.gov/36017572/
  4. https://www.acc.org/Latest-in-Cardiology/ten-points-to-remember/2022/09/02/14/23/2022-ESC-Guidelines-for-VAs-ESC-2022
  5. https://pubmed.ncbi.nlm.nih.gov/26320108/

2. ACC/AHA/HRS Guideline for the Evaluation and Management of Patients with Ventricular Arrhythmias

  1. https://www.ahajournals.org/doi/10.1161/CIR.0000000000000549
  2. https://www.hrsonline.org/guidance/clinical-resources/2017-accahahrs-guideline-evaluation-and-management-patients-syncope
  3. https://www.ahajournals.org/doi/10.1161/cir.0000000000000499
  4. https://pubmed.ncbi.nlm.nih.gov/29097320/
  5. https://www.jacc.org/doi/10.1016/j.jacc.2017.03.003

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